| 名稱 | TP53 p.G245D Reference Standard 標(biāo)準(zhǔn)品 |
| 型號 | CBP10153 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | TP53 p.G245D Reference Standard |
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電話：4008750250
號碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號
Email： zhangxiangwen@cobioer.com
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基因檢測標(biāo)準(zhǔn)品 > Mutation > CBP10153TP53 p.G245D Reference Standard 標(biāo)準(zhǔn)品
- 詳細(xì)內(nèi)容
CBP10153 | |
| Format | Genomic DNA |
| Description | TP53 G245D is a hotspot mutation that lies within the DNA binding domain of the Tp53 protein (PMID: 22713868). G245D results in decreased activation of Tp53 target genes (PMID: 22214764, PMID: 25634208, PMID: 27533082), and also confers a gain-of-function to Tp53 as demonstrated by aberrant interaction with ZBP-89, as well as induction of FOXM1 expression, and leads to decreased apoptosis in culture and increased tumor growth and metastasis in mouse models (PMID: 22214764, PMID: 29269868). |
| Technical Data | |
| DNA Change: | c.734G>A |
| AA Change | p.G245D |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | ENST00000269305 |
| Cosmic ID | COSM43606 |
| Chr position(GRCh37) | chr17:7577547 |
| Buffer: | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing | Download for COA |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
